Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDSSARS-CoV-2에 의해 유발된 ARDS 생존자의 폐 기능 및 방사선학적 특징과 관련된 순환 microRNA 프로파일 식별Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, [키워드] acute respiratory distress syndrome Anti-inflammatory ARDS association carbon monoxide cell death Chest computed tomography circulating Coagulation Complete composed Computed tomography conducted correlated COVID-19 develop diffusing diffusing capacity distress enrichment analyses enrichment analysis evaluated Evidence evidence of feature Features Follow-up Gene ontology genomes hospital discharge hypoxia identification immune response infected patient infected patients KEGG KEGG pathway Kyoto lung Lung function median microRNA miR-126 miR-146 miR-146a-5p miR-21 miR-9 miRNA miRNA profiles miRNA profiling miRNA signature molecular molecular mechanism molecular mechanisms Pathogenesis pathophysiology pathway Patient patients predicted profile provided Pulmonary function radiologic radiological feature radiological features Random forest respiratory distress Respiratory distress syndrome RT-qPCR SARS-COV-2 infection secondary to sequelae severe COVID-19 severity survivor to define total severity score. Trial registration TSS vascularization viral infection was performed was used [DOI] 10.1080/22221751.2022.2081615 PMC 바로가기 [Article Type] Article
COVID-19 and the injured patient: A multicenter reviewResearch article Published on 2022-12-012022-10-05 Journal: The Journal of surgical research [Category] 바이오마커, [키워드] adverse events Affect age Analysis baseline characteristics C-reactive protein Coagulopathy Cohort collected Comorbidities composed Coronavirus disease 2019 COVID-19 cumulative D-dimer demographics diabetes events ferritin Frame Hospitalization hypertension In-hospital death Injury ISS Kaplan–Meier method log-rank test median morbidity and mortality Mortality multicenter neurologic New York Older outcome outcomes Patient patients performed physiological Primary outcome Result Retrospective analysis severity shown study period surgical tested trauma trauma patient trauma patients were excluded were used [DOI] 10.1016/j.jss.2022.06.068 [Article Type] Research article
A nasal omicron vaccine booster elicits potent neutralizing antibody response against emerging SARS-CoV-2 variants비강 오미크론 백신 부스터는 새로운 SARS-CoV-2 변이체에 대한 강력한 중화 항체 반응을 이끌어냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] absence adjuvants administration antibody Antibody Response boost booster Bronchoalveolar lavage caused clinical trial composed COVID-19 COVID-19 pandemic current deaths delta variant described disease severity domain dose effective Elevation elicit evidenced FIVE fused human infection human infections humans IgA Immunity immunogen intranasal leads mice MOST mucosal nasal nasal protein vaccine booster Neutralizing activity neutralizing antibody Neutralizing antibody response omicron Omicron variant omicron variant. Protein Receptor binding domain reduce respiratory SARS-CoV-2 SARS-CoV-2 nucleoprotein SARS-CoV-2 spike SARS-CoV-2 transmission SARS-CoV-2 variant severity significantly single dose suggested the antibody response the disease vaccination Vaccine virus infection wild-type [DOI] 10.1080/22221751.2022.2053365 PMC 바로가기 [Article Type] Article
Photocatalytic degradation of COVID-19 related drug arbidol hydrochloride by Ti3C2 MXene/supramolecular g-C3N4 Schottky junction photocatalystArticle Published on 2022-12-012022-11-15 Journal: Chemosphere [Category] 치료제, [키워드] Affect antiviral drug Arbidol arbidol hydrochloride composed COVID-19 COVID-19 outbreak Degradation drug increasingly less mechanism pathway Photocatalytic degradatiion provide Result resulting Schottky junction SEM significantly superoxide radical Supramolecular g-C(3)N(4) TEM Ti(3)C(2). Toxicity Treatment [DOI] 10.1016/j.chemosphere.2022.136461 PMC 바로가기
SARS-CoV-2 RNA load in nasopharyngeal specimens from outpatients with breakthrough COVID-19 due to Omicron BA.1 and BA.2Article Published on 2022-12-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome All participant BA.1 BA.2 Booster vaccine caused collected comparable composed coronavirus coronavirus disease COVID-19 Day Diagnosis dose elapsed had no Infection log median median age nasopharyngeal specimen omicron Omicron variant Outpatient Patient reached retrospective RNA SARS-CoV-2 SARS-CoV-2 RNA Support symptom onset TaqPath Thermo Fisher Scientific time Transmissibility upper respiratory tract URT vaccination schedule Vaccine vaccine dose Viral load Viral load. viral RNA load was used [DOI] 10.1002/jmv.28079 PMC 바로가기
Clinical, laboratory and immunohistochemical characterization of in situ pulmonary arterial thrombosis in fatal COVID-19Article Published on 2022-11-012022-11-15 Journal: Thrombosis research [Category] SARS, 바이오마커, [키워드] Admission age Artery characterized clinical Coagulopathy composed contribute controls coronavirus COVID-19 COVID-19 patient Critical disease D-dimer died disease disease severity elevations eosin evaluated Evidence fatal COVID-19 FEU Hypoxemia ICU immunohistochemistry in both groups Inflammation Inflammatory IQR Laboratory laboratory feature LDH lung main role marker neutrophil organ damage parenchymal damage Patient Platelet Pneumonia pneumonia case post-mortem lung pulmonary thrombi selected serum significantly higher thrombosis thrombosis. transfer WBC White blood cell [DOI] 10.1016/j.thromres.2022.09.012 PMC 바로가기
Traditional Chinese medicine combined with Moxibustion in the treatment of “long-COVID”: A protocol for systematic review and meta-analysisArticle Published on 2022-10-282022-11-16 Journal: Medicine [Category] meta-analysis, [키워드] benefit carried China Chinese composed COVID-19 database Efficacy and safety eight evaluate evaluated Evidence exclusion criteria Inclusion Infrastructure international public health journal knowledge lack Meta-analysis moxibustion patients with COVID-19 prevalent protocol Randomized controlled trial Research risk Science screened symptoms of COVID-19 systematic review technology Traditional Chinese medicine treat Treatment was used Web of Science [DOI] 10.1097/MD.0000000000031447 PMC 바로가기
Inflammatory myopathy following coronavirus disease 2019 vaccination: A systematic reviewArticle Published on 2022-10-212022-11-15 Journal: Frontiers in Public Health [Category] 진단, [키워드] accompanied adverse event antibodies article autoantibodies autoantibody BNT162b2 ChAdOx1 Clinical course clinical feature complications composed conducted coronavirus disease coronavirus disease 2019 vaccine COVID-19 COVID-19 vaccination COVID-19 vaccine critical appraisal dermatomyositis Follow-up identify Immune-mediated IMPROVE independent induce Inflammatory inflammatory myopathy investigator Joanna Briggs Institute management muscular myositis myositis specific autoantibodies. occurred Onset Patient patients presenting proportion report reported Risk of bias SARS-CoV-2 SARS-CoV-2 vaccine searched Side effect skin rash Specific subtype Symptom systematic review Treatment vaccination Vaccine vaccine dose weakness were used [DOI] 10.3389/fpubh.2022.1007637 PMC 바로가기
A novel vaccine based on SARS-CoV-2 CD4+ and CD8+ T cell conserved epitopes from variants Alpha to OmicronArticle Published on 2022-10-062022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 100% conserved Analysis Antigen Beta caused CD4 CD4+ CD8 CD8+ T cell clade clades composed confirmed cases conserved COVID-19 cross-protective deaths Delta epitope Epitopes Epsilon Eta Gamma Genome genomes GISAID greater highly antigenic HLA binding hydrophobic IFN-γ IL-10 IL-12 IL-2 IL-6 immune response immune responses immunoinformatics in silico approaches in vivo Lambda long-lasting majority memory Metadata molecular docking Mortality Mutation non-toxic offer omicron ORF ORF1ab ORF8 proteins peptide performed promoted Protein reduced Reinfection SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variants secretion severity Strains suffered T cell epitope TGF-β Th1 the Spike the vaccine TLR4 Vaccine variant variants virus virus transmission WHO Wuhan [DOI] 10.1038/s41598-022-21207-2 PMC 바로가기
External quality assessment of SARS-CoV-2 serology in European expert laboratories, April 2021Article Published on 2022-10-012022-11-15 Journal: Eurosurveillance [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibodies characterisation collected composed country COVID-19 Critical detect Diagnosis diagnostics eight epidemiological EQA Europe European evaluate External human SARS-CoV-2 human serum immune response Immunoglobulin indicated involved Laboratory mitigate natural infection neutralising antibody participant performed provided public health measures robust SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody responses SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2 transmission Sensitivity and specificity serological serological test serology Serology. Support the vaccine Vaccine [DOI] 10.2807/1560-7917.ES.2022.27.42.2101057 PMC 바로가기